Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
In Marseilles a skilled pizza delivery boy Daniel who drives a scooter finally has his dreams come true. He gets a taxi license. Caught by the police for a huge speed infraction, he will help Emilien, a loser inspector who can't drive, on the track of German bank robbers, so he doesn't lose his license and his dream job.
In a picture-perfect seaside town, an insurance salesman begins to realize that his entire existence may be staged and observed by a vast unseen audience as part of a long-running real-time reality TV show.